Quickstart:
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*Unpack to your harddrive.
*run TESVSGM.exe
*select "Advanced" -> "Change play-button link" to browse to your Skyrim executable if necessary.
*select "Savegames" -> "Scan For New Profiles"
*select the profile you want to play from the dropdown list
*click "Play" button to lunch Skyrim: The Elder Scrolls V and play with the active profile